Key result
The components of the cardiac conduction system originate from embryonic myocardium that maintains its primitive phenotype, whereas adjacent myocardium differentiates into working myocardium.
This review clarifies that the cardiac conduction system develops from embryonic myocardium retaining a primitive phenotype, providing foundational knowledge for future regenerative therapies.
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Clarifies embryonic origins of the conduction system; leaves open translational implications for congenital arrhythmias.
Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to limited knowledge of the molecular regulation of pacemaker myocardium. Origin and development of the cardiac conduction system have been subject to debate for many decades. This review will discuss recent advances in our understanding of the molecular regulation of the development of the conduction system. We conclude that the components of the cardiac conduction system originate from embryonic myocardium that has maintained essential features of its primitive phenotype, whereas the adjacent myocardium differentiates into working myocardium.
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Bakker et al. (2010) conducted a review in Disorders of the cardiac conduction system. The components of the cardiac conduction system originate from embryonic myocardium that maintains its primitive phenotype, whereas adjacent myocardium differentiates into working myocardium.
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