November 15, 1999Development

Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage

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Population

Developing looped, tubular heart models

Design

Preclinical

Authors

GCGang ChengShangrao Normal University WLWanda H. LitchenbergCollege of Charleston GCGregory J. ColeNorth Carolina Central University

Discussion

Member takes

Implication

Challenges neuroectodermal origin models; extends multipotent cardiomyocyte progenitor mapping but leaves open human translation.

Structured PICO

Population

Developing looped, tubular heart models

Intervention

Lineage-tracing strategies using replication-incompetent adenoviral and retroviral lacZ-expressing constructs and [(3)H]thymidine label dilution

Outcome

Cellular derivation and lineage relationships of peripheral and central conduction tissues

The cardiac conduction system develops through progressive recruitment of multipotent cardiomyogenic cells rather than from neuroectoderm or a prespecified pool of primary myogenic progenitors.

Cite This Study

Cheng et al. (1999) studied this question.

synapsesocial.com/papers/6a7aa9518a3ae1c74232eae8 https://doi.org/10.1242/dev.126.22.5041

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Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider