Key result
A transgenic mouse line expressing a lacZ reporter gene delineated the developing murine cardiac conduction system, demonstrating that patterning and function occur early in embryogenesis.
Population
Transgenic mice with lacZ reporter gene expression delineating the developing and mature murine cardiac…
Design
Preclinical
Authors
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No immediate clinical implications; extends molecular tools for investigating conduction system development.
Identification of a transgenic mouse line with a lacZ reporter provides a novel tool for exploring the molecular circuitry controlling mammalian conduction system development.
Rentschler et al. (2001) studied Cardiac conduction system development. lacZ reporter gene transgenic mice was evaluated on lacZ expression and optical mapping of cardiac electrical activity. A transgenic mouse line expressing a lacZ reporter gene delineated the developing murine cardiac conduction system, demonstrating that patterning and function occur early in embryogenesis.