Key result
Rutin and quercetin prevented oxaliplatin-induced thermal and mechanical nociceptive responses in male mice by reducing oxidative stress in the spinal cord.
Why the study?
Do rutin and quercetin prevent oxaliplatin-induced painful peripheral neuropathy in mice?
Population
Male Swiss mice injected with oxaliplatin (1 mg/kg, i.v.) twice a week (total of nine injections)
Comparison
Rutin and quercetin injected 30 min before each… vs Oxaliplatin alone (implied control group)
Design
Preclinical
Authors
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Does not support clinical use for oxaliplatin neuropathy prevention; leaves open whether rutin or quercetin merit human trials.
Do rutin and quercetin prevent oxaliplatin-induced painful peripheral neuropathy in mice?
Rutin and quercetin prevent oxaliplatin-induced painful peripheral neuropathy in mice by reducing oxidative stress and preserving dorsal horn structure.
Azevedo et al. (2013) studied Oxaliplatin-induced chronic painful peripheral neuropathy. Rutin and quercetin vs. Oxaliplatin alone was evaluated on Thermal and mechanical allodynia. Rutin and quercetin prevented oxaliplatin-induced thermal and mechanical nociceptive responses in male mice by reducing oxidative stress in the spinal cord.
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