What question did this study set out to answer?

The aim is to efficiently produce the enantiopure compound (S)-BTPE using immobilized ketoreductases.

July 21, 2023ChemCatChem

Biocatalytic Asymmetric Synthesis of (S)‐1‐3,5‐bis(trifluoromethyl)phenylethanol by an Immobilized KRED in Batch and Flow Conditions

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Randomized trial demonstrates efficient synthesis of enantiopure BTPE using immobilized KRED, highlighting its industrial applicability.

The aim is to efficiently produce the enantiopure compound (S)-BTPE using immobilized ketoreductases.
Utilized a commercial KRED biocatalyst after immobilization on various supports.
Optimized reaction conditions including temperature and solvent for batch and flow systems.
Conducted biotransformations under optimized conditions to evaluate substrate conversion and enantiomeric excess.
Achieved complete conversion after 24 hours in flow conditions with enantiomeric excess greater than 99.9%.
Best substrate conversion was obtained using a 90:10 (v/v) IPA:water solvent system at 30 °C.
Successfully demonstrated reusability of the immobilized biocatalyst over five reaction cycles.

Armani et al. (2023) studied this question.

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