Key result
Exendin-4 significantly ameliorated warfarin-associated hemorrhagic transformation and preserved blood-brain barrier integrity after cerebral ischemia in mice.
Why the study?
Does exendin-4 reduce warfarin-associated hemorrhagic transformation after cerebral ischemia in a mouse model?
Does exendin-4 reduce warfarin-associated hemorrhagic transformation after cerebral ischemia in a mouse model?
p-value: p=<0.05
In a mouse model of cerebral ischemia, exendin-4 reduced warfarin-associated hemorrhagic transformation and neuroinflammation via the PI3K/Akt/GSK-3β pathway.
No takes yet. Share an insight, caveat, or question.
May reduce warfarin-associated HT; hypothesis-generating for GLP-1R agonists before clinical translation.
Chen et al. (2016) studied Warfarin-associated hemorrhagic transformation after cerebral ischemia. Exendin-4 vs. Saline was evaluated on Hemorrhagic transformation (brain hemoglobin levels) and blood-brain barrier integrity at 72 hours post-MCAO (p=<0.05). Exendin-4 significantly ameliorated warfarin-associated hemorrhagic transformation and preserved blood-brain barrier integrity after cerebral ischemia in mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: