Key result
Intra-aortic balloon pump without routine anticoagulation therapy was safe, resulting in significantly less minor bleeding compared to intravenous heparin (2.4% vs 11.3%, P<0.05) and no clot deposits.
Why the study?
Does intravenous heparin anticoagulation prevent clot deposits or vascular complications in patients undergoing intra-aortic balloon pump counterpulsation?
Population
153 patients undergoing intra-aortic balloon pump (IABP) counterpulsation
Comparison
Intravenous heparin with target aPTT 50-70… vs No intravenous heparin during balloon pumping
Design
RCT, randomly assigned into two groups
Follow-up
24 hours post IABP removal
Authors
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IABP without anticoagulation may be feasible in select patients; leaves open need for randomized trials before practice change.
RCT (n=153)
randomly assigned
No
Does intravenous heparin anticoagulation prevent clot deposits or vascular complications in patients undergoing intra-aortic balloon pump counterpulsation?
Absolute Event Rate: 11.3% vs 2.4%
p-value: p=<0.05
Routine anticoagulation with intravenous heparin during IABP counterpulsation does not prevent clot deposits or limb ischemia but significantly increases the risk of bleeding complications.
Jiang et al. (2003) conducted an RCT in Intra-aortic balloon pump (IABP) patients (n=153). Intravenous heparin vs. No intravenous heparin was evaluated on Minor bleeding (p=<0.05). Intra-aortic balloon pump without routine anticoagulation therapy was safe, resulting in significantly less minor bleeding compared to intravenous heparin (2.4% vs 11.3%, P<0.05) and no clot deposits.
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