Thiazolidinediones play a positive role in the vascular endothelium and inhibit plaque progression in diabetic patients with coronary atherosclerosis: A systematic review and meta-analysis

FIGURE 1. The flow diagram of the literature research and study selection according to the PRISMA guidelines.

FIGURE 2. Schematic representation of the risk of bias.

FIGURE 3. TZDs slowed the progression of plaque attachment on the vascular endothelium. (A) The relationship above vessel volume, lumen volume, and plaque volume; the materials in the figure were provided by Servier Medical Art (https://smart.servier.com) under a CC BY 3.0 license. (B) Effect of the TZDs on the vessel volume (mm3/mm). (C) Effect of the TZDs on the lumen volume (mm3/mm). (D) Effect of the TZDs on the plaque volume (mm3/mm).

FIGURE 4. TZDs increased adiponectin but didn’t affect CRP and IL-6 significantly. (A) Effect of the TZDs on the adiponectin. (B) Effect of the TZDs on the CRP (mg/L). (C) Effect of the TZDs on the IL-6 (ng/L).

FIGURE 5. The effect of the TZDs on the serum lipid profile was unstable. (A) Effect of the TZDs on TG (mmol/L). (B) Effect of the TZDs on TC (mmol/L). (C) Effect of the TZDs on LDL-C (mmol/L). (D) Effect of the TZDs on HDL-C (mmol/L).

FIGURE 6. The role played by adiponectin in endothelium-related vascular diseases and the relationship between adiponectin and the inflammatory markers including CRP and IL-6; the material in the picture was provided Friendly by Figdraw (https://www.figdraw.com).