Key result
Morchella esculenta polysaccharide alleviates atherosclerosis and lowers serum lipids in preclinical models.
Answers are grounded in this paper and cite their sources.
) mice were fed high-fat diet (HFD) and administered intragastrically (i.g.) with saline or MCP dissolved in saline for 15 weeks. We found that MCP inhibited en face and sinus lesions. Moreover, serum levels of total and low-density lipoprotein cholesterol and triglyceride were decreased by MCP. The HFD-induced hepatic lipid accumulation was also attenuated by MCP. The underlying molecular mechanisms of anti-atherogenic and lipogenic effects of MCP might be attributed to reduced cholesterol synthesis by activating AMPKα signaling pathway and inhibiting SREBP2 expression. In addition, MCP-decreased serum triglyceride level is related to inhibiting LXRα expression. Taken together, these results indicate that MCP markedly alleviates atherosclerosis and M. esculenta can be used as a functional food additive to benefit patients with atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2021) studied Atherosclerosis. Polysaccharide MCP extracted from Morchella esculenta vs. Saline was evaluated on Atherosclerosis lesions (en face and sinus) and serum lipid levels. Polysaccharide MCP from Morchella esculenta alleviated atherosclerosis, decreased serum lipids, and attenuated hepatic lipid accumulation in LDLR-deficient mice fed a high-fat diet for 15 weeks.
Synapse has enriched 10 related papers. Consider them for comparative context: