Key result
Maternal thrombophilia is linked to ~1200 g lower newborn birth weight compared to healthy pregnancy.
Why the study?
Women with thrombophilia are more likely to experience difficulties during pregnancy that affect newborn development, prompting a comparison of maternal and newborn characteristics between healthy and thrombophilic pregnancies.
Does thrombophilic pregnancy and its treatment affect maternal and newborn characteristics compared to healthy pregnancy?
Cohort (n=350)
Does thrombophilic pregnancy and its treatment affect maternal and newborn characteristics compared to healthy pregnancy?
Answers are grounded in this paper and cite their sources.
Appropriately treated normal-weight pregnant women with thrombophilia have similar newborn outcomes to healthy pregnant women, though higher maternal weight and LMWH doses correlate with lower birth weight.
A thrombophilic woman is more likely to experience difficulties during pregnancy, difficulties that will also affect the development of the newborn. This study aims to compare maternal and newborn characteristics between healthy and thrombophilic pregnancy. The following characteristics were analysed: maternal characteristics (BMI- body mass index, haemostasis parameters, thrombophilia-specific treatment) and newborn characteristics (gestational period, birth weight, the Apgar score). This follow-up study spanning five years, from 2018 to 2022, focuses on a cohort of 500 women who underwent delivery hospitalization in the western region of Romania. The maternal characteristics influence the newborn: the greater the weight of the mother with thrombophilia, the more the chances that the fetus will have a lower birth weight; increasing the dose of LMWH (low molecular weight heparin), connected with the necessity to control the homeostasis parameters, the more likely the fetus will be born with a lower birth weight. A pregnant woman with thrombophilia, treated appropriately, having a normal weight, and not presenting other risk factors independent of thrombophilia, will have a newborn with characteristics similar to a healthy pregnant woman.
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Samfireag et al. (2023) conducted a cohort in Thrombophilia in pregnancy (n=350). Thrombophilia vs. Healthy pregnancy was evaluated on Newborn birth weight (mean) (p=<0.05). Pregnant women with thrombophilia delivered newborns with lower mean birth weights compared to healthy pregnant women.
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