Aortic stenosis: even mild disease is significant
Key result
In adults with asymptomatic mild to moderate aortic stenosis, coexisting coronary artery disease was associated with lower 3-year event-free survival compared to no coronary disease (63% vs 86%).
Population
176 initially asymptomatic adults with mild to moderate aortic stenosis
Design
Editorial
Follow-up
average of 4 years
Authors
Discussion
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Member takes
Implication
Mild to moderate asymptomatic aortic stenosis has a high rate of progression to severe disease and adverse outcomes, emphasizing the importance of regular echocardiographic follow-up and risk factor management.
Structured PICO
P
Population
176 initially asymptomatic adults with mild to moderate aortic stenosis followed for an average of 4 years.
O
Outcome
Clinical outcomes including progression to severe aortic stenosis (aortic jet velocity >4.0m/s), requirement for valve replacement, and deathhard clinical
Main Result
Absolute Event Rate: 63% vs 86%
Mild to moderate asymptomatic aortic stenosis has a high rate of progression to severe disease and adverse outcomes, emphasizing the importance of regular echocardiographic follow-up and risk factor management.
Limitations
- Small sample size
Cite This Study
Catherine M Otto (2004) conducted an editorial in Asymptomatic mild to moderate aortic stenosis (n=176). Coronary artery disease vs. No coronary artery disease was evaluated on Event-free survival at 3 years. In adults with asymptomatic mild to moderate aortic stenosis, coexisting coronary artery disease was associated with lower 3-year event-free survival compared to no coronary disease (63% vs 86%).