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An optimal pH is maintained in each secretory and endocytic organelle by the balance between active H(+) pumping and passive H(+) efflux. The progressive acidification of secretory organelles does not reflect an increased proton pumping activity but rather the decreased conduction of a "proton leak" pathway resembling the recently cloned voltage-gated proton channels.
Nicolas Demaurex (Fri,) studied this question.