Key result
High carotid stiffness measured by ARTSENS Touch in a community setting was significantly associated with the clustering of multiple cardiometabolic risk factors, with an age-adjusted odds ratio of 3.33 for Ep ≥ 143.51 kPa in females.
Why the study?
The field feasibility of carotid stiffness measurement using ARTSENS Touch had not been investigated, and community-level data from India were lacking.
Cross-Sectional (n=1,074)
No
The ARTSENS Touch device demonstrates field feasibility for measuring carotid arterial stiffness in community settings, showing expected associations with age and cardiometabolic risk factors.
Answers are grounded in this paper and cite their sources.
May enable community carotid stiffness screening in India; leaves open prognostic validation in diverse populations.
Objective: We investigate the field feasibility of carotid stiffness measurement using ARTSENS® Touch and report the first community-level data from India. Method: In an analytical cross-sectional survey among 1074 adults, we measured specific stiffness index (β), pressure-strain elastic modulus (Eₚ), arterial compliance (AC), and one-point pulse wave velocity (PWVβ) from the left common carotid artery. Data for established risk factors (waist circumference, blood pressure, plasma glucose, triglycerides, and HDL-C) were also collected. The association of carotid stiffness with age, gender, hypertension/diabetes, smoking, and clustering of risk factors was studied. Results: Measurements were repeatable with a relative difference (RD) between consecutive readings of~ 80% of arterial diameter values. The average RDs forβ,Eₚ, AC, and PWVβ, were 20.51%, 22.31%, 25.10%, and 14.13%, respectively. Typical range for stiffness indices among females and males wereβ: 8.12 ± 3.59 vs 6.51 ± 2.78,Eₚ: 113.24 ± 56.12 kPa vs 92.33 ± 40.65 kPa, PWVβ: 6.32 ± 1.38 ms−1vs 5.81 ± 1.16 ms−1, and AC: 0.54 ± 0.36 mm2kPa−1vs 0.72 ± 0.38 mm2kPa−1. Meanβ,Eₚ, and PWVβincreased (and mean AC decreased) across decades of age; the trend persisted even after excluding hypertensives and subjects with diabetes. The odds ratio of presence of multiple risk factors forEₚ ≥93.71kPa and/or PWVβ ≥6.56ms−1was ≥ 2.12 or above in males. In females, it was just above 2.00 forEₚ ≥91.21kPa and/or PWVβ ≥5.10ms−1and increased to ≥ 3.33 forEₚ ≥143.50kPa and ≥ 3.25 for PWVβ ≥7.31ms−1. Conclusion: The study demonstrated the feasibility of carotid stiffness measurement in a community setting. A positive association between the risk factors and carotid artery stiffness provides evidence for the device’s use in resource-constrained settings. Clinical Impact: The device paves the way for epidemiological and clinical studies that are essential for establishing population-level nomograms for wide-spread use of carotid stiffness in clinical practice and field screening of ‘at-risk’ subjects.
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Joseph et al. (2020) conducted a cross-sectional in Cardiometabolic risk factors (n=1,074). High carotid stiffness (Ep ≥ 143.51 kPa) vs. Lower carotid stiffness was evaluated on Presence of multiple (≥3) cardiometabolic risk factors in females (OR 3.33, 95% CI 1.78-6.25). High carotid stiffness measured by ARTSENS Touch in a community setting was significantly associated with the clustering of multiple cardiometabolic risk factors, with an age-adjusted odds ratio of 3.33 for Ep ≥ 143.51 kPa in females.
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