Key result
Enteroviruses were detected in 24.4% of clinical samples and 40.4% of sewage samples, revealing a close relationship between serotypes shed in stools and those isolated from the environment.
Cross-Sectional (n=510)
No
There is a close relationship between enterovirus serotypes shed in stools and isolated from the environment, though some discrepancies exist due to detection limitations.
May enhance EV surveillance via sewage in Indian cities; leaves open need for validation against clinical outcomes.
BACKGROUND: The Enterovirus (EV) surveillance system is inadequate in densely populated cities in India. EV can be shed in feces for several weeks; these viruses are not easily inactivated and may persist in sewage for long periods. Surveillance and epidemiological study of EV-related disease is necessary. METHODS: In this study, we compare the EV found in sewage with clinically isolated samples. Tissue culture was used for isolation of the virus and serotype confirmed by enterovirus neutralization tests. RESULTS: We found positive cases for enterovirus from clinical and sewage samples and identified additional isolates as echovirus 9, 11, 25 & 30 by sequencing. CONCLUSION: There is a close relation among the serotypes of enterovirus shed in stools and isolated from the environment but few serotypes which were detected in sewage samples were not found clinically and the few which were detected clinically not found in sewage because some viruses are difficult to detect by the cell culture method.This study will be helpful for the researchers who are working on polio and nonpolio enterovirus especially in the countries which are struggling for polio eradication.
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Tiwari et al. (2018) conducted a cross-sectional in Acute flaccid paralysis / Enterovirus infection (n=510). Environmental sewage and clinical stool sampling was evaluated on Enterovirus positivity rate. Enteroviruses were detected in 24.4% of clinical samples and 40.4% of sewage samples, revealing a close relationship between serotypes shed in stools and those isolated from the environment.
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