Pathogenesis of Peptic Ulcer and Implications for Therapy

ALTHOUGH several features of peptic ulcer disease have been elucidated over the past few years, new questions have replaced those that have been answered. Some of the factors that may predispose people to the development of peptic ulcers have been identified, but how they produce their effects and how they can be combated therapeutically remain unclear. This seminar briefly reviews current knowledge about the pathogenesis of peptic ulcers and discusses strategies for treatment.Defense of Normal Mucosa against Acid and Peptic InjuryThree basic levels of defense underlie the remarkable ability of normal gastroduodenal mucosa to resist injury from the . . .