Key result
Aspirin ingestion was significantly associated with overt gastrointestinal haemorrhage, whereas alcohol alone was not; however, their combination demonstrated a highly significant synergistic effect.
Why the study?
Does the ingestion of aspirin, alcohol, or their combination increase the risk of gastrointestinal haemorrhage?
Population
817 patients admitted for gastrointestinal haemorrhage and two control groups
Comparison
Ingestion of aspirin, alcohol, or a combination… vs Two control groups
Design
Case-control
Authors
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Aspirin with alcohol warrants clinical caution for GI bleed risk; confirms association in Level 5 data but leaves causality open.
Case-Control (n=817)
Does the ingestion of aspirin, alcohol, or their combination increase the risk of gastrointestinal haemorrhage?
Aspirin ingestion is significantly associated with gastrointestinal haemorrhage, and this risk is synergistically increased when combined with alcohol.
Needham et al. (1971) conducted a case-control in Gastrointestinal haemorrhage (n=817). Aspirin and alcohol vs. Control groups was evaluated on Overt gastrointestinal haemorrhage. Aspirin ingestion was significantly associated with overt gastrointestinal haemorrhage, whereas alcohol alone was not; however, their combination demonstrated a highly significant synergistic effect.
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