Key result
The C allele of the CYP11B2 T-344C gene polymorphism was significantly associated with an increased risk of atrial fibrillation (OR 1.26).
Why the study?
Does the CYP11B2 T-344C gene polymorphism increase the risk of atrial fibrillation?
Meta-Analysis (n=2,758)
Does the CYP11B2 T-344C gene polymorphism increase the risk of atrial fibrillation?
Odds Ratio: 1.26 (95% CI 1.11–1.42)
p-value: p=0.0002
Individuals with the C allele of the CYP11B2 T-344C gene polymorphism have a significantly higher risk for developing atrial fibrillation.
Supports AF genetic risk research; leaves open clinical genotyping or targeted interventions pending validation.
BACKGROUND: Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting. OBJECTIVE AND METHODS: A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed- or random-effects model. RESULTS: A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11-1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26-3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820-0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130-1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070-1.243, P = 1.0×10(-10)) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956-1.131, P = 0.361). CONCLUSIONS: A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.
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Li et al. (2012) conducted a meta-analysis in Atrial Fibrillation (n=2,758). CYP11B2 T-344C gene polymorphism (C allele) vs. T allele was evaluated on Atrial fibrillation risk (allelic model) (OR 1.26, 95% CI 1.11-1.42, p=0.0002). The C allele of the CYP11B2 T-344C gene polymorphism was significantly associated with an increased risk of atrial fibrillation (OR 1.26).
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