Key result
NIDDM was associated with significantly higher carotid artery intimal-medial thickness compared to nondiabetic patients (1.39 vs. 1.24 mm, P<0.001), independent of other risk factors.
Why the study?
Is intimal-medial thickness of the carotid artery greater in NIDDM patients compared to nondiabetic patients, and is it associated with insulin resistance?
Cross-Sectional (n=114)
Is intimal-medial thickness of the carotid artery greater in NIDDM patients compared to nondiabetic patients, and is it associated with insulin resistance?
Absolute Event Rate: 1.39% vs 1.24%
p-value: p=<0.001
Type 2 diabetes is associated with greater carotid intimal-medial thickness independent of other established risk factors, and this early atherosclerosis is independently associated with insulin resistance in diabetic patients.
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Greater carotid IMT in NIDDM signals possible early atherosclerosis; leaves open insulin resistance as independent driver in observational data.
Bonora et al. (1997) conducted a cross-sectional in NIDDM (Type 2 Diabetes) (n=114). NIDDM vs. Nondiabetic patients was evaluated on Intimal-medial thickness (IMT) of the carotid artery (p=<0.001). NIDDM was associated with significantly higher carotid artery intimal-medial thickness compared to nondiabetic patients (1.39 vs. 1.24 mm, P<0.001), independent of other risk factors.
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