Key result
LuQi Formula demonstrates cardioprotective effects in heart failure by inhibiting myocardial fibrosis, decreasing collagen deposition and brain natriuretic peptide levels, and improving heart function.
Why the study?
Heart failure remains a major clinical burden, and there is a need to summarize clinical and laboratory research on LuQi Formula and its cardioprotective mechanisms to guide further drug development.
LuQi Formula shows potential cardioprotective effects in heart failure models by inhibiting fibrosis and improving heart function, warranting further mechanistic studies.
Should not yet change heart failure practice; leaves open LuQi Formula efficacy pending rigorous trials.
Heart failure is the terminal stage of cardiovascular diseases. In the population-aging trend, it remains a serious social problem with high morbidity, mortality, and rehospitalization rates. Traditional Chinese medicine has long been used to treat heart failure. LuQi Formula was modified by Professor Zhou Hua of Shuguang Hospital, Shanghai, based on years of clinical experience and the concept of the “heart-kidney intersection.” It has been proven effective in the treatment of heart failure, and is beneficial in inhibiting myocardial fibrosis, decreasing collagen deposition and brain natriuretic peptide levels, improving heart function in rats with acute myocardial infarction, and affecting adenosine triphosphate production. In this review, we summarized the clinical and laboratory research on LuQi Formula, and the mechanism of the cardioprotective effect of each medicine in this recipe. This review offers a theoretical basis and research direction for further mechanistic studies on LuQi Formula to foster its development into new cardiovascular drugs.
No takes yet. Share an insight, caveat, or question.
Feng et al. (2022) conducted a review in Heart failure. LuQi Formula was evaluated. LuQi Formula demonstrates cardioprotective effects in heart failure by inhibiting myocardial fibrosis, decreasing collagen deposition and brain natriuretic peptide levels, and improving heart function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: