Key result
Dexmedetomidine 1 μg/kg IV significantly attenuated the heart rate and blood pressure responses to laryngoscopy and intubation compared to labetalol 0.25 mg/kg.
Why the study?
The study was conducted to compare the effectiveness of dexmedetomidine versus labetalol in attenuating haemodynamic stress responses to laryngoscopy and intubation, as well as their post-operative sedation and adverse effects.
Does dexmedetomidine attenuate hemodynamic stress responses to laryngoscopy and intubation better than labetalol in patients undergoing elective surgeries under general anaesthesia?
RCT (n=60)
Single-blind
Randomly divided in two groups
No
Does dexmedetomidine attenuate hemodynamic stress responses to laryngoscopy and intubation better than labetalol in patients undergoing elective surgeries under general anaesthesia?
Dexmedetomidine is more effective than labetalol in attenuating the hemodynamic stress response to laryngoscopy and endotracheal intubation.
Supports further investigation of dexmedetomidine for intubation hemodynamics; leaves open routine use pending larger trials.
Background: We hypothesized that the effectiveness of dexmedetomidine versus labetalol in attenuation of hemodynamic stress responses of laryngoscopy and intubation and effect of dexmedetomidine in post-operative sedation .Also we studied adverse effect of both the drugs.Method: Following approval by institutional ethics committee and 60 patients, who posted for elective surgeries under general anaesthesia taken. Study drug was given in 100 ml of saline over 10 mins. Inj dexmedetomine 1 microgram/ kg and Inj. labetalol 0.25 mg/kg given and parameters like HR, SBP, DBP, Spo2, and sedation score were monitored immediately and after 3,5 and 10 minutes.Result: There was a reduction in the heart rate and mean arterial pressure response to intubation in both Dexmedetomidine and labetalol but there was statistically significant reduction of heart rate and arterial pressure response to intubation in Dexmedetomidine group. There was statistically significant sedation in Dexmedetomidine group.Conclusion: Dexmedetomidine 1μ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.
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Patel et al. (2021) conducted an RCT in Elective surgeries under general anaesthesia (n=60). Dexmedetomidine vs. Labetalol 0.25 mg/kg IV over 10 mins was evaluated on Attenuation of haemodynamic stress responses (heart rate and blood pressure) to laryngoscopy and intubation (p=<0.05). Dexmedetomidine 1 μg/kg IV significantly attenuated the heart rate and blood pressure responses to laryngoscopy and intubation compared to labetalol 0.25 mg/kg.
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