Key result
Dexmedetomidine blunts post-intubation heart rate and blood pressure increases more effectively than esmolol.
Why the study?
Does intravenous dexmedetomidine compared to intravenous esmolol improve hemodynamic stability during laryngoscopy and endotracheal intubation in elective general surgery patients?
RCT (n=60)
Observer blind
Chit method
No
Does intravenous dexmedetomidine compared to intravenous esmolol improve hemodynamic stability during laryngoscopy and endotracheal intubation in elective general surgery patients?
Absolute Event Rate: 81.33% vs 86.93%
p-value: p=<0.0001
Intravenous dexmedetomidine (1 μg/kg) is more effective than esmolol (1 mg/kg) for attenuating the hemodynamic stress response to laryngoscopy and intubation.
Dexmedetomidine may be preferred over esmolol for intubation hemodynamics; extends RCT evidence in elective surgery.
Background: The present study compares the effects of I.V. dexmedetomidine and I.V. esmolol on hemodynamic response occurring due to laryngoscopy and endotracheal intubation in elective general surgery.Methods: A total of 60 patients aged 18-60 years, American Society of Anesthesiologists physical status I or II, either sex, scheduled for elective surgical procedures were included in this study. Patients were randomly allocated by chit method into two equal groups of 30 each, comprising of group dexmedetomidine (group D) 1 μg/kg diluted with 0.9% saline to 10 ml I.V. over 10min and group esmolol (group E) 1 mg/kg diluted with 0.9% saline to 10 ml I.V. given just before induction. Heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were recorded at baseline, after 5 min of infusion, after induction and at 1, 3, 5 and 10 min after endotracheal intubation.Results: In group D, there was no statistically significant increase in HR and blood pressure after intubation at any time intervals, where as in group E, there was a statistically significant increase in blood pressure and heart rate after intubation at 1, 3, 5 and 10 min.Conclusions: Dexmedetomidine 1 μg/kg is more effective than esmolol for attenuating the hemodynamic response to laryngoscopy and intubation in elective surgical patients.
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Gupta et al. (2016) conducted an RCT in Elective surgical procedures requiring general anesthesia and endotracheal intubation (n=60). Dexmedetomidine vs. Esmolol 1 mg/kg IV bolus was evaluated on Heart rate at 1 minute after intubation (beats/min) (p=<0.0001). Intravenous dexmedetomidine (1 μg/kg) significantly attenuated the increase in heart rate (81.33 vs 86.93 beats/min, p<0.0001) and blood pressure at 1 minute after intubation compared to esmolol.
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