Comparative Study to Evaluate Attenuation of Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation Using Intravenous Esmolol and Intravenous Dexmedetomidine

BACKGROUND a highly selective α2 ‑ adrenoreceptor agonist and esmolol an ‑ short‑acting β1 ‑ cardioselective adrenergic receptor blocker appear to be suitable to control the detrimental effects of laryngeal and tracheal . The study was conducted to compare the efficacy of dexmedetomidine esmolol for attenuation of hemodynamic responses to laryngoscopy and 200 patients of age 18–60 years, belonging to American Society of (ASA) physical state of I & II of either are posted for elective procedure randomized into two groups of 100 each to receive (Group D): 1 μg / Kg in 20 mL normal saline over 10 mins, 7 . prior to intubation and esmolol (Group E) : 1 mg / Kg over 1 min, 2 min prior intubation. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP) any side effects associated the drugs during the study, i.e., 15 min of intubation, were observed and analysed. statistically significant difference (p < 0.01) between Groups D and E was in mean heart rate (HR), systolic blood pressure (SBP), diastolic blood (DBP), mean arterial pressure (MAP) during intubation, 1 min, 3 min, 5 & 15 min after intubation. was better as compared to esmolol in attenuation of response to laryngoscopy and tracheal intubation.