Comparative Study Between Intravenous Dexmedetomidine and Esmolol for Attenuation of Hemodynamic Response to Endotracheal Intubation-a Double Blinded Study

Background: On laryngoscopy patients protective airway reflex are triggered which in turn triggers the sympathetic nervous system and causes release of catecholamines.These release of hormones causes hemodynamic changes such as tachycardia, raises blood pressure and arrhythmias. Materials And Methods:This is a randomised control study,to be done in total of 60 American Society of Anaesthesiologists 1 and 2 patients,aged 18–60 years randomly divided into two groups; who are posted for undergoing elective surgeries under department of anaesthesia at Sree Balaji medical college and hospital,Chennai.Group D includes 30 patients received intravenous dexmedetomidine 1mcg/kg in 50 ml normal saline which was infused in 10 minutes before induction and 2 mins prior to intubation 20 ml normal saline was given as bolus over 30 seconds. Group E includes 30 patients received intravenous 50 ml of normal saline which was infused 10 minutes before induction and 2 mins prior to intubation 20 ml of normal saline containing 0.5mg/kg esmolol was given as bolus over 30 seconds.Results:Among the total participants means age was 48.47 in group E and 47.87 in group D.There was no statistically significance found among the age between two study groups (P value 0.605).There is no statistical difference in baseline parameters between two groups for heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure. There is statistically significant difference between the both group with respect to Heart rate, systolic BP,diastolic BP and MAP (P=0.0002) for 1 min, 3mins and 5 mins post intubation. Hence it showed that group D had better control over the heart rate when compared to group E. Conclusion:We conclude in this study that dexmedetomidine and esmolol both has significant effect in reducing the hemodynamic related stress response to laryngoscope as well as intubation with less adverse effects.