Key result
Labetalol monotherapy provided adequate blood pressure control in 27 of 41 patients (65.9%) with essential or renal hypertension, without reducing overall renal function.
Why the study?
Does labetalol monotherapy adequately control blood pressure in hypertensive patients with normal and impaired renal function?
Does labetalol monotherapy adequately control blood pressure in hypertensive patients with normal and impaired renal function?
Labetalol monotherapy controlled BP in most patients without postural effects or renal decline; hypothesis-generating and should not yet change practice.
1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150--2,400 mg daily for periods ranging from 1--64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.
No takes yet. Share an insight, caveat, or question.
Thompson et al. (1979) studied Hypertension with normal and impaired renal function (n=41). Labetalol was evaluated on Adequate blood pressure control. Labetalol monotherapy provided adequate blood pressure control in 27 of 41 patients (65.9%) with essential or renal hypertension, without reducing overall renal function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: