Key result
Brain glucose levels during hypoglycemia were comparable between patients with type 1 diabetes and healthy subjects (0.6 vs 0.5 μmol/g; P=0.52), with no difference in glucose transport kinetics.
Why the study?
Does the relationship between plasma and brain glucose levels during euglycemia and hypoglycemia differ between healthy subjects and patients with type 1 diabetes?
Population
17 subjects (8 healthy subjects and 9 patients with uncomplicated type 1 diabetes mellitus, HbA1c 7.7 ± 1.4%)
Comparison
Hyperinsulinemic euglycemic and hypoglycemic… vs Healthy subjects vs. T1DM patients
Design
Cross-sectional
Authors
Loading...
No evidence of altered brain glucose transport in uncomplicated T1DM; extends linear kinetics to hypoglycemia but leaves open relevance to awareness.
Observational (n=17)
Does the relationship between plasma and brain glucose levels during euglycemia and hypoglycemia differ between healthy subjects and patients with type 1 diabetes?
Absolute Event Rate: 0.6% vs 0.5%
p-value: p=0.52
The linear Michaelis-Menten relationship between plasma and brain glucose extends to low plasma glucose levels, with no difference in blood-brain barrier glucose transport kinetics between healthy subjects and patients with well-controlled T1DM.
Ven et al. (2012) conducted an observational in Type 1 diabetes mellitus (n=17). Type 1 diabetes mellitus vs. Healthy subjects was evaluated on Brain glucose levels during hypoglycemia (μmol/g) (p=0.52). Brain glucose levels during hypoglycemia were comparable between patients with type 1 diabetes and healthy subjects (0.6 vs 0.5 μmol/g; P=0.52), with no difference in glucose transport kinetics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: