Key result
Mild hypoglycemia preferentially activated limbic-striatal brain regions and significantly increased hunger ratings (5.7 vs 4.5, P=0.009) and desire for high-calorie foods compared to euglycemia.
Why the study?
Does mild hypoglycemia alter neural control and increase the desire for high-calorie foods in obese and nonobese individuals?
Does mild hypoglycemia alter neural control and increase the desire for high-calorie foods in obese and nonobese individuals?
Absolute Event Rate: 5.7% vs 4.5%
p-value: p=0.009
Circulating glucose modulates neural control over food motivation, and the glucose-linked restraining influence of the medial prefrontal cortex is lost in obesity.
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May link glycemia to food-cue reactivity in obesity; hypothesis-generating for glucose-targeted appetite interventions.
Page et al. (2011) studied Healthy volunteers (obese and nonobese) (n=21). Mild hypoglycemia via stepped hyperinsulinemic euglycemic-hypoglycemic clamp vs. Euglycemia (target ~90 mg/dl) was evaluated on Hunger ratings (p=0.009). Mild hypoglycemia preferentially activated limbic-striatal brain regions and significantly increased hunger ratings (5.7 vs 4.5, P=0.009) and desire for high-calorie foods compared to euglycemia.
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