Using a series of yeast artificial chromosomes (YAC) from the 8p11-12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases. Genes Chromosom Cancer 15:191–194 (1996).
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Soenen et al. (1996) studied this question.
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