Key result
Ten weeks of oral sodium nitrite supplementation (80 or 160 mg/day) increased endothelial function by 45-60% versus baseline (P<0.10) and improved carotid artery elasticity (P<0.05).
Why the study?
Does oral sodium nitrite supplementation improve vascular function in middle-aged and older adults?
RCT
double blind
randomized
Does oral sodium nitrite supplementation improve vascular function in middle-aged and older adults?
p-value: p=<0.10
Oral sodium nitrite supplementation improves endothelial function and lessens carotid artery stiffening in middle-aged and older adults, suggesting a potential therapy for age-related vascular dysfunction.
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Sodium nitrite may safely improve vascular function in middle-aged adults; extends mouse data to humans and supports larger efficacy trials.
DeVan et al. (2015) reported an RCT. Sodium nitrite vs. Placebo was evaluated on Endothelial function (brachial artery flow-mediated dilation) (p=<0.10). Ten weeks of oral sodium nitrite supplementation (80 or 160 mg/day) increased endothelial function by 45-60% versus baseline (P<0.10) and improved carotid artery elasticity (P<0.05).
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