Key result
Complete genome sequencing of Enterovirus 80 strain HZ01/SD/CHN/2004 revealed 79.5% similarity with the prototype strain and an insertion of 36 nucleotides in the VP1 coding region.
Effect estimate: 79.5% similarity
This is the first report of the complete genome of Enterovirus 80 in China, revealing genetic divergence and recombination.
EV80 genome now sequenced in China; extends enterovirus surveillance data but leaves clinical role in AFP open.
Enterovirus 80 (EV80) is a newly identified serotype of the species Human enterovirus B. An EV80 strain designated HZ01/SD/CHN/2004 was isolated from an acute flaccid paralysis case in Shandong, China, in 2004. Complete genome comparison revealed 79.5% similarity with the prototype strain and an insertion of 36 nucleotides in the 3' end of the VP1 coding region. Intertypic recombination with other serotypes was observed. This is the first report of the complete genome of EV80 in China.
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Tao et al. (2012) studied Acute flaccid paralysis (n=1). Enterovirus 80 strain HZ01/SD/CHN/2004 genome sequencing vs. Prototype strain was evaluated on Complete genome sequence similarity (79.5% similarity). Complete genome sequencing of Enterovirus 80 strain HZ01/SD/CHN/2004 revealed 79.5% similarity with the prototype strain and an insertion of 36 nucleotides in the VP1 coding region.
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