Key result
In five patients with antiphospholipid syndrome, multiple subungual splinter hemorrhages occurred concomitantly with thrombotic events of diverse arterial sites, suggesting a thrombotic mechanism.
Case Report (n=5)
Multiple subungual splinter hemorrhages in antiphospholipid syndrome are likely thrombotic in mechanism and occur concomitantly with arterial thrombotic events.
Subungual splinter hemorrhages may signal APS in SLE; leaves open diagnostic specificity beyond endocarditis.
Multiple subungual splinter hemorrhages have been initially described as an important sign of subacute endocarditis. Secondly, they were reported in various other conditions, especially in isolated cases of primary antiphospholipid syndrome. We report five patients with multiple fingernail subungual splinter hemorrhages occurring in the course of antiphospholipid syndrome. Antiphospholipid syndrome was secondary to systemic lupus erythematosus in two, to Fasciola hepatica infection in one and was considered as primary in two. In all patients multiple subungual splinter hemorrhages occurred concomitantly with thrombotic events of diverse arterial sites. The mechanism of subungual splinter hemorrhages is most probably thrombotic.
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Françès et al. (1994) conducted a case report in Antiphospholipid syndrome (n=5). Antiphospholipid syndrome was evaluated on Thrombotic events of diverse arterial sites. In five patients with antiphospholipid syndrome, multiple subungual splinter hemorrhages occurred concomitantly with thrombotic events of diverse arterial sites, suggesting a thrombotic mechanism.
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