Before-and-after study demonstrates reduced severe hyperoxemia in mechanically ventilated patients, indicating guidelines may help improve oxygen management.
Key Points
Evaluate the effectiveness and safety of an oxygen titration guideline to reduce hyperoxemia in mechanically ventilated emergency department patients.
Before-and-after study design with 1111 patients (625 preintervention, 486 postintervention)
Implemented an oxygen titration guideline to target reduced hyperoxemia
Analyzed outcomes including incidences of hyperoxemia and hypoxemia, ICU and hospital length of stay, and in-hospital mortality
Severe hyperoxemia incidence decreased from 39.4% to 30%, aOR 0.68 (95% CI 0.51-0.91), p=0.01.
Hypoxemia incidence increased from 7.5% to 13%, aOR 1.87 (95% CI 1.22-2.88), p<0.01.
No significant differences in ICU length of stay, hospital length of stay, or in-hospital mortality; median time on ventilator increased slightly.