Intratumoral Fusobacterium species and survival in resectable colorectal cancer: a multicenter cohort study

Key Points

This research aims to evaluate the prognostic significance of intratumoral Fusobacterium species in patients with resectable colorectal cancer.
Patients with stage I to III colorectal cancer were enrolled at nine centers.
Intratumoral Fusobacterium spp. was detected using RNA in situ hybridization.
Correlations were analyzed between Fusobacterium positivity and clinical outcomes such as recurrence-free survival and disease-free survival.
21% of patients had Fusobacterium-positive tumors, which were associated with shorter recurrence-free survival (HR 1.87, 95% CI 1.23-2.84, P=0.003).
Adjuvant chemotherapy improved disease-free survival in Fusobacterium-negative patients (HR 0.38, 95% CI 0.20-0.74, P=0.004) but not in Fusobacterium-positive patients.
Post-operative Fusobacterium nucleatum positivity in stool was linked to an increased risk of relapse (OR 61.0, 95% CI 2.3-1652, P=0.01).

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Multicenter cohort study reveals Fusobacterium spp. presence affects survival in colorectal cancer, implying potential for tailored treatments.

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Serna et al. (2026) studied this question.

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