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August 1, 2026MicroorganismsOpen Access

Isolation, Identification, and Biological Characterization of Proteus mirabilis Isolated from Beef Cattle in China

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Authors

XGXueli GeRGRongjun GongJMJiamin Ma

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Overview

Randomized trial assesses pathogenicity and resistance of Proteus mirabilis in cattle, suggesting health risks in production systems.

Key Points

  • To isolate and characterize the Proteus mirabilis strain A3 from beef cattle and evaluate its antimicrobial resistance and pathogenic potential.
  • Isolated strain A3 from 19 diarrheic beef cattle in Anhui Province, China.
  • Conducted phenotypic, genomic, and pathogenicity analyses, including whole-genome sequencing.
  • Utilized mouse infection models to assess pathogenicity at different bacterial doses.
  • Strain A3 demonstrated a multidrug-resistant phenotype with multiple virulence genes identified.
  • Infection with high dosage (2.22 × 10^9 CFU/mL) resulted in 100% mortality in mice within 12 hours.
  • Whole-genome sequencing revealed substantial genomic plasticity with a high average nucleotide identity to other bovine strains.

Cite This Study

Ge et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9819e258b358b3c6afefhttps://doi.org/10.3390/microorganisms14081668
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