Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 1, 2026Experimental and Molecular PathologyOpen Access

Neutrophil extracellular traps induced by a monoclonal anti-phosphatidylserine/prothrombin antibody activate platelets in vitro

View Full Paper
Ask AI
Bookmark
Share

Authors

SASuishin AraiKTKoki TakaiHMHiyori Miyatake

Discussion

Loading...

Member takes

Overview

Randomized trial reveals that aPS/PT-induced NETs activate platelets in APS, suggesting new treatment strategies.

Key Points

  • This study aims to clarify how aPS/PT-induced NETs affect platelet activation and their role in thrombo-inflammatory responses in APS.
  • NETs were induced using a monoclonal aPS/PT antibody on neutrophils from healthy donors.
  • Proteomic analyses compared protein compositions of aPS/PT-induced NETs and ANCA-induced NETs.
  • Functional inhibition assays assessed the impact of blocking candidate proteins on platelet activation.
  • aPS/PT binding induced NET formation with larger and more fibrous morphology than ANCA-induced NETs.
  • Platelets in aPS/PT-induced NETs showed significantly higher activation than those in ANCA-induced NETs.
  • Proteomic analysis identified histone H3 as a mediator of platelet activation, with higher plasma concentrations in APS patients.

Cite This Study

Arai et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9833e258b358b3c6b461https://doi.org/10.1016/j.yexmp.2026.105070
View Full Paper
Ask AI
Bookmark
Share