Key result
Hereditary antithrombin deficiency linked to markedly higher VTE risk during pregnancy, requiring individualized anticoagulation.
Why the study?
Hereditary antithrombin deficiency is a high-risk thrombophilia associated with markedly increased maternal venous thromboembolism risk during pregnancy and postpartum.
Does individualized anticoagulation and multidisciplinary care optimize outcomes in pregnant women with hereditary antithrombin deficiency?
Does individualized anticoagulation and multidisciplinary care optimize outcomes in pregnant women with hereditary antithrombin deficiency?
Individualized anticoagulation and multidisciplinary care are essential to mitigate the markedly increased risk of maternal venous thromboembolism in pregnant women with hereditary antithrombin deficiency.
May warrant individualized LMWH strategies in antithrombin-deficient pregnancies; leaves open prospective validation of replacement protocols.
Hereditary antithrombin deficiency is a high-risk thrombophilia associated with markedly increased maternal venous thromboembolism risk during pregnancy and postpartum. Individualized anticoagulation strategies with low-molecular-weight heparin, selective antithrombin concentrate replacement and multidisciplinary care optimize maternal and fetal outcomes.
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Afolabi et al. (2026) studied this question. Hereditary antithrombin deficiency markedly increases maternal venous thromboembolism risk during pregnancy and postpartum, requiring individualized anticoagulation to optimize outcomes.
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