Key result
Widespread use of anticoagulants is not advised due to low VTE incidence, but low molecular weight heparin is supported for high and intermediate-risk pregnant women with inherited thrombophilia.
Why the study?
Does low molecular weight heparin prevent venous thromboembolism in pregnant women with inherited thrombophilia?
Does low molecular weight heparin prevent venous thromboembolism in pregnant women with inherited thrombophilia?
This review highlights that while pregnancy and inherited thrombophilia increase VTE risk, widespread anticoagulation is not recommended except for high and intermediate-risk women.
LMWH may warrant consideration in high- and intermediate-risk pregnant women with inherited thrombophilia; leaves open need for RCTs to confirm VTE prevention.
PURPOSE OF REVIEW: This review summarizes the currently available data concerning risk and management of venous thromboembolism in pregnant women with inherited thrombophilia. SUMMARY: Pregnancy is a hypercoagulable state, and inherited thrombophilia increases this risk further. Despite the risks, the actual incidence of venous thromboembolism remains low, and therefore, the widespread use of anticoagulants for pregnant women with inherited thrombophilia is not advised. Although randomized, placebo-controlled trials investigating the risks and benefits of anticoagulation have not been performed, there are data to support the use of low molecular weight heparin for high and intermediate-risk women. We will review these data and treatment recommendations, which are based on retrospective and case-control studies as well as expert opinion and consensus statements.
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Fogerty et al. (2009) conducted a review in Inherited thrombophilia in pregnancy. Anticoagulants (low molecular weight heparin) was evaluated on Venous thromboembolism. Widespread use of anticoagulants is not advised due to low VTE incidence, but low molecular weight heparin is supported for high and intermediate-risk pregnant women with inherited thrombophilia.
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