Key result
Single-stage PFO closure, nephrectomy, and IVC thrombectomy successfully treats pediatric Wilms tumor with intracardiac extension.
Why the study?
Wilms tumor with intravascular extension poses significant surgical challenges, particularly when combined with a patent foramen ovale due to the risk of paradoxical embolism.
Case Report (n=1)
No
A one-stage procedure combining surgical PFO closure and Wilms tumor resection with IVC thrombectomy is feasible and prevents paradoxical embolism in complex pediatric oncology cases.
Single-stage surgery remains investigational in pediatric Wilms tumor with PFO; hypothesis-generating and requires prospective studies before wider adoption.
Wilms tumor with intravascular extension poses significant surgical challenges, particularly when combined with a patent foramen ovale, which adds the risk of paradoxical embolism. We report the first case hitherto reported of a 5‐year‐old boy successfully treated in a single‐stage procedure combining surgical PFO closure, nephrectomy, and inferior vena cava thrombectomy. The child recovered uneventfully and remains without complications and tumor‐free at 6‐month follow‐up. This case highlights the importance of thorough preoperative assessment in nephroblastoma patients and demonstrates the value of interdisciplinary collaboration in managing rare and complex pediatric oncologic scenarios.
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Hammer et al. (2026) conducted a case report in Wilms tumor with inferior vena cava thrombus and patent foramen ovale (n=1). Simultaneous surgical PFO closure, nephrectomy, and IVC thrombectomy was evaluated on Surgical success and clinical status at 6 months. A 5-year-old boy with Wilms tumor, IVC thrombus, and PFO was successfully treated with a single-stage procedure combining surgical PFO closure, nephrectomy, and IVC thrombectomy.
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