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July 30, 2026Science

Signatures of aging and disease in a single organelle

Jeeyoon Na Anne Brunet

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Key Points

The aim is to investigate how changes in lysosomal metabolites relate to aging and lysosomal storage diseases.
Examined metabolic profiles of lysosomal components in aging organs
Analyzed the correlation with lysosomal storage diseases
Identified significant alterations in lysosomal metabolites associated with aging
Established connections between abnormal metabolite profiles and lysosomal storage diseases

Implication

Study reveals metabolic changes in lysosomes linked to aging organs and storage diseases, suggesting biomarkers for health assessment.

Abstract

Changes in lysosomal metabolites are associated with both aging organs and lysosomal storage diseases

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Cite This Study

Na et al. (2026) studied this question.

synapsesocial.com/papers/6a6d985be258b358b3c6ba07 https://doi.org/10.1126/science.aej5901

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Keep reading

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