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August 1, 2026Infectious Microbes & DiseasesOpen Access

Multiomics Analysis Identifies Microbiota, Immune and Metabolomics Changes Across Disease Stages of COVID-19: A Retrospective Study

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Authors

FGFangfang GengFirst Affiliated Hospital Zhejiang UniversityTYTongtong YuanTengzhou Central People's HospitalTXTingting XiaoNational Clinical Research Center for Digestive Diseases

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Overview

Retrospective study identifies microbiota and immune alterations across COVID-19 severity stages, suggesting predictive biomarkers.

Key Points

  • This study aims to characterize alterations in microbiota, immune profiles, and metabolomics in COVID-19 patients across disease stages and develop a predictive model for progression.
  • Retrospective analysis of 35 healthy controls and 101 COVID-19 patients with varied severity.
  • Assessment of oral and gut microbiomes, serum metabolome, and immune cell profiles.
  • Development of a predictive model integrating clinical and microbiota data.
  • COVID-19 patients showed reduced microbial diversity and changes in specific bacterial populations.
  • Serum metabolomics revealed altered lysine degradation patterns in severe cases.
  • Severe patients had lower frequencies of critical immune cells, impacting early immune response.

Cite This Study

Geng et al. (2026) studied this question.

synapsesocial.com/papers/6a6d985be258b358b3c6ba24https://doi.org/10.1097/im9.0000000000000215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome–Metabolome Crosstalk as a Driver of COVID-19 Severity2026
  2. 2Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients2024 · 1 citations
  3. 3Longitudinal multi-omic dynamics in hospitalized COVID-19 patients based on disease severity2026
  4. 4Prognostic Prediction in COVID-19 Patients: A Comprehensive Analysis of Gut Microbiota and Hematological Biomarkers2026
  5. 5High-resolution multi-omics defines respiratory microbiome and host signatures of COVID-19 severity2026