What question did this study set out to answer?

The study aims to investigate how decorin interacts with PDGF in the corneal stroma to affect keratocyte motility and migration.

PDGF-Stimulated Corneal Keratocyte Motility and Migration Patterns on Aligned Collagen Fibrils Are Inhibited by Decorin

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In vitro model demonstrates that decorin inhibits PDGF-mediated keratocyte motility, suggesting implications for corneal healing.

The study aims to investigate how decorin interacts with PDGF in the corneal stroma to affect keratocyte motility and migration.
Used an in vitro model of decorin-coated aligned collagen fibrils to simulate corneal stroma
Examined effects of PDGF-BB stimulation on keratocyte behavior
Analyzed cell alignment, motility, and receptor phosphorylation
Decorin reduced keratocyte alignment and increased random migration in wounded areas
Inhibition of PDGFRβ phosphorylation indicative of suppressed PDGF signaling
Observed shifted cell morphology from elongated to stellate with decorin presence

Tjahjono et al. (2026) studied this question.

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