What is the clinical evidence from this study?

Study design: RCT. Population: ST-segment elevation myocardial infarction (STEMI) (n=179). Intervention: Very early discharge (≤48 hours) vs. Routine discharge (>48 hours). Primary outcome: Major adverse cardiovascular events (MACE) at 3 months (p=1.00).

What does this research mean for the field?

Very early discharge (≤48 hours) after successful primary PCI in selected low-risk STEMI patients does not increase major adverse cardiovascular events at 3 months compared with routine discharge. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the safety and feasibility of very early discharge (≤48 hours) compared to routine discharge (>48 hours) following successful primary percutaneous coronary intervention in low-risk STEMI patients.

August 1, 2026CureusOpen Access

Very Early Discharge After Primary Percutaneous Coronary Intervention (PCI) in Low-Risk ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Safety and Feasibility From a Prospective Randomized Study

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Key result

Very early discharge after primary PCI for low-risk STEMI shows no difference in 3-month MACE.

P=1.00
n=179

Why the study?

Serious post-procedural complications are uncommon beyond 24 hours in stable STEMI patients, but prospective randomized data evaluating very early discharge remain limited, especially in resource-constrained settings.

Does very early discharge (≤48 hours) compared to routine discharge (>48 hours) increase major adverse cardiovascular events in low-risk STEMI patients after successful primary PCI?

Population

179 selected low-risk STEMI patients after successful primary PCI

Comparison

Very early discharge (≤48 hours) vs routine discharge (>48 hours)

Design

Prospective, randomized, open-label, single-center study

Follow-up

3 months

Authors

AYAbdelkarim Ait Yahya WDWissame DahmaneCadi Ayyad University MZM. ZtatiCardiac Imaging

Discussion

Member takes

Implication

Supports very early discharge in selected low-risk STEMI after successful PCI; extends observational data with randomized evidence.

Key Points

To assess the safety and feasibility of very early discharge (≤48 hours) compared to routine discharge (>48 hours) following successful primary percutaneous coronary intervention in low-risk STEMI patients.
Prospective, randomized, open-label, single-center trial conducted at Mohammed VI University Hospital Center in Marrakech, Morocco between June 2024 and June 2025.
Randomized 179 low-risk STEMI patients with preserved left ventricular ejection fraction (>50%), TIMI 3 flow, and no 24-hour complications 1:1 to very early discharge (≤48 hours, n=82) or routine discharge (>48 hours, n=97).
Assessed the primary composite endpoint of major adverse cardiovascular events (MACE) at three months, comprising all-cause mortality, recurrent myocardial infarction, heart failure hospitalization, and stent thrombosis.
The primary endpoint of MACE occurred in 2 of 82 patients (2.4%) in the early discharge group versus 2 of 97 patients (2.1%) in the routine discharge group (p = 1.00; log-rank p = 0.86).
Individual components in the early discharge arm included 1 death (1.2%) and 1 heart failure hospitalization (1.2%), compared to 1 recurrent myocardial infarction (1.0%), 1 heart failure hospitalization (1.0%), and 0 deaths (0.0%, p = 0.46) in routine discharge.
Zero cases of definite or probable stent thrombosis occurred in either treatment group during follow-up, and the median hospital stay for the early discharge group was 25.8 hours.

Study Design

Type

RCT (n=179)

Blinding

Open-label

Randomization

1:1 ratio using a computer-generated randomization sequence

Multicenter

Structured PICO

Does very early discharge (≤48 hours) compared to routine discharge (>48 hours) increase major adverse cardiovascular events in low-risk STEMI patients after successful primary PCI?

Population

179 low-risk patients with STEMI and preserved left ventricular ejection fraction who underwent successful primary PCI, followed for 3 months.

Intervention

Very early discharge (≤48 hours, median 25.8 hours) after successful primary percutaneous coronary intervention (PCI).

Comparator

Routine discharge (>48 hours) after successful primary percutaneous coronary intervention (PCI).

Outcome

Major adverse cardiovascular events (MACE) at 3 months, defined as a composite of all-cause mortality, recurrent myocardial infarction, hospitalization for heart failure, and definite or probable stent thrombosis.composite

Main Result

Absolute Event Rate: 2.4% vs 2.1%

p-value: p=1.00

Very early discharge (≤48 hours) after successful primary PCI in selected low-risk STEMI patients appears safe and feasible, with no increase in 3-month MACE compared to routine discharge.

Limitations

Single center with a relatively modest sample size and no formal a priori sample size calculation
Open-label design without blinding
Follow-up period limited to three months
No formal allocation concealment procedure
Trial not prospectively registered
Single center with a relatively modest sample size
No formal a priori sample size calculation
Short follow-up period limited to three months
Trial was not prospectively registered

Cite This Study

Yahya et al. (2026) conducted an RCT in ST-segment elevation myocardial infarction (STEMI) (n=179). Very early discharge (≤48 hours) vs. Routine discharge (>48 hours) was evaluated on Major adverse cardiovascular events (MACE) at 3 months (p=1.00). Very early discharge (≤48 hours) after successful primary PCI in low-risk STEMI patients resulted in similar rates of 3-month MACE compared to routine discharge (2.4% vs 2.1%, p=1.00).

synapsesocial.com/papers/6a6d9868e258b358b3c6bc92 https://doi.org/10.7759/cureus.113670

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Very Early Discharge After Primary Percutaneous Coronary Intervention (PCI) in Low-Risk ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Safety and Feasibility From a Prospective Randomized Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Very Early Discharge After Primary Percutaneous Coronary Intervention (PCI) in Low-Risk ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Safety and Feasibility From a Prospective Randomized Study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

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