What question did this study set out to answer?

This review aims to explore immune microenvironment signatures that affect the efficacy of immune checkpoint inhibitors in solid tumors.

August 1, 2026Discover OncologyOpen Access

Multiomic immune microenvironment signatures associated with response and resistance to immune checkpoint blockade across solid tumours

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Authors

FAFasogbon Samuel AyobamiMedical Laboratory Science Council of Nigeria IUIniobong Anselem UdoAiredale NHS Foundation Trust KOKevin OdegaSt George's Hospital

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Implication

Review highlights immune microenvironment signatures affecting response to immune checkpoint inhibitors, suggesting new predictive biomarkers for better patient stratification.

Key Points

This review aims to explore immune microenvironment signatures that affect the efficacy of immune checkpoint inhibitors in solid tumors.
Analyzed the role of multi-omic technologies such as genomics, transcriptomics, and proteomics.
Reviewed various immunophenotypes and their influence on T-cell activation and treatment response across solid tumors.
Discussed recent advancements in identifying composite biomarkers for predicting ICI responses.
Highlighted the significance of TME immunophenotypes in determining responses to treatment.
Identified several key immune-microenvironment signatures associated with therapeutic success or failure.
Proposed a framework for patient stratification using mechanistic insights and emerging technologies.

Cite This Study

Ayobami et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9874e258b358b3c6bcf5 https://doi.org/10.1007/s12672-026-05652-3

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Implication

Review highlights immune microenvironment signatures affecting response to immune checkpoint inhibitors, suggesting new predictive biomarkers for better patient stratification.

Multiomic immune microenvironment signatures associated with response and resistance to immune checkpoint blockade across solid tumours

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiomic immune microenvironment signatures associated with response and resistance to immune checkpoint blockade across solid tumours

Discussion

Member takes

Implication

Key Points

Cite This Study

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