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August 1, 2026Amyloid

Short-axis deep skin biopsy sections detect wild-type ATTR in 83% of cases, outperforming long-axis sections.

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Why the study?

Does the sectioning method (short-axis vs long-axis) of deep excisional skin biopsy affect the detection rate of wild-type ATTR cardiac amyloidosis?

Comparison

Short-axis sections with vertical cuts vs long-axis sections with a horizontal cut

Key result

Deep excisional skin biopsy including abdominal fat detected wild-type ATTR in 83% of short-axis sections compared to 54% of long-axis sections.

Authors

KHKohei HondaIOIkoi OmatsuTYTetsuhiro Yamano

Discussion

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Overview

Short-axis sectioning may enhance cardiac wtATTR detection; leaves open standardized protocols for clinical biopsies.

Key Points

  • This research aims to evaluate the diagnostic utility of deep excisional skin biopsies in identifying transthyretin cardiac amyloidosis.
  • Conducted a deep excisional skin biopsy including abdominal fat
  • Used Congo red staining and anti-TTR antibody staining for analysis
  • Calculated detection rates for wild-type ATTR in various tissue sections
  • Detection rate for short-axis sections was 83%
  • Detection rate for long-axis sections was 54%
  • Highlighted the effectiveness of deep excisional skin biopsy in diagnosing transthyretin cardiac amyloidosis

Study Design

Type

Observational

Structured PICO

Does the sectioning method (short-axis vs long-axis) of deep excisional skin biopsy affect the detection rate of wild-type ATTR cardiac amyloidosis?

P
Population
Patients evaluated for wild-type transthyretin cardiac amyloidosis (ATTR)
E
Exposure
Deep excisional skin biopsy including abdominal fat (short-axis sections)
C
Comparator
Long-axis sections
O
Outcome
Detection rate for wild-type ATTRsurrogate

Main Result

Absolute Event Rate: 83% vs 54%

Short-axis sections of deep excisional skin biopsies including abdominal fat yield a higher detection rate (83%) for wild-type ATTR compared to long-axis sections (54%).

Cite This Study

Honda et al. (2026) conducted an observational in Transthyretin cardiac amyloidosis. Deep excisional skin biopsy (short-axis sections) vs. Deep excisional skin biopsy (long-axis sections) was evaluated on Detection rate for wild-type ATTR. Deep excisional skin biopsy including abdominal fat detected wild-type ATTR in 83% of short-axis sections compared to 54% of long-axis sections.

synapsesocial.com/papers/6a6d9874e258b358b3c6bd3fhttps://doi.org/10.1080/13506129.2026.2711143
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