What question did this study set out to answer?

The aim is to understand how disseminated tumor cells (DTCs) interact with their tumor microenvironment (TME) during metastatic colonization.

August 1, 2026Open Access

Spatiotemporal multi-omics uncover tumor ecosystem dynamics driving metastatic colonization

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Randomized trial uncovers tumor ecosystem dynamics during metastatic colonization, suggesting important interactions in immune responses.

The aim is to understand how disseminated tumor cells (DTCs) interact with their tumor microenvironment (TME) during metastatic colonization.
Integrated multimodal single-cell and spatial profiling with digital pathology
Tracked dynamics of DTCs from single-cell seeding to overt metastases
Utilized mouse models and patient samples for analysis
Identified a transient population of quiescent Phgdhhigh DTCs that survived immune clearance during seeding
Uncovered co-evolution of DTCs and TME during the metastasis process
Provided insights into the immune evasion mechanisms of DTCs leading to metastasis

钟裕(Yu Zhong) (2026) studied this question.

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