Concerns Regarding Brain [ ¹⁸ F]FDG SUV mean as a Prognostic Biomarker in Advanced Non–Small Cell Lung Cancer

Eray Alper; Efrah Ahmed Ibrahim

doi:10.2967/jnumed.126.272807

July 30, 2026Journal of Nuclear Medicine

Concerns Regarding Brain [ ¹⁸ F]FDG SUV mean as a Prognostic Biomarker in Advanced Non–Small Cell Lung Cancer

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Key Points

To address issues with the use of whole-brain FDG SUVmean as a prognostic biomarker for overall survival in advanced non-small cell lung cancer.
Critical review of the proposed biomarker in the context of existing literature.
Analysis of potential confounding factors affecting FDG SUVmean measurement.
Express concerns about the independent prognostic ability of FDG SUVmean.
Highlight the need for further validation and consideration of confounding factors.

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Implication

This letter questions the validity of whole-brain FDG SUVmean as a prognostic marker in advanced non-small cell lung cancer, suggesting potential oversights.

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Cite This Study

Alper et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9885e258b358b3c6bfba https://doi.org/10.2967/jnumed.126.272807

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Concerns Regarding Brain [ ¹⁸ F]FDG SUV mean as a Prognostic Biomarker in Advanced Non–Small Cell Lung Cancer

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Concerns Regarding Brain [ ¹⁸ F]FDG SUV mean as a Prognostic Biomarker in Advanced Non–Small Cell Lung Cancer

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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