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July 29, 2026Oral Diseases

c‐Myc‐Regulated lnc RNA AFAP1‐AS1 Promotes Proliferation of Oral Squamous Cell Carcinoma via the miR‐655‐3p/CCNA2 Axis

Panpan Liu Qian Wu Tao Li

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Key Points

This study investigates how AFAP1-AS1 promotes cell growth in oral squamous cell carcinoma.
Examined AFAP1-AS1 levels in OSCC tissues and cell lines
Silenced AFAP1-AS1 in vitro to assess changes in CCNA2
Used dual-luciferase reporter assays and RNA immunoprecipitation to validate miRNA interactions
AFAP1-AS1 expression significantly higher in OSCC tissues and cell lines compared to normal controls
Silencing AFAP1-AS1 resulted in decreased CCNA2 expression
ChIP assays confirmed c-Myc directly binds to the AFAP1-AS1 promoter region

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Implication

Reveals that AFAP1-AS1 promotes OSCC proliferation via the miR-655-3p/CCNA2 axis, suggesting new therapeutic targets.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a6d989ee258b358b3c6c299 https://doi.org/10.1111/odi.70450

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