What question did this study set out to answer?

This review aims to synthesize evidence on the causes of obstetric shock beyond hemorrhage, particularly focusing on microcirculatory and metabolic dysfunctions.

August 1, 2026Maternal-Fetal MedicineOpen Access

Obstetric Shock Beyond Hemorrhage: Microcirculatory Shunting, Endothelial Glycocalyx Injury, and Mitochondrial Failure in Pregnancy—A Narrative Review

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Authors

TRTheresia Monica RahardjoMaranatha Christian University ASAloysius SuryawanMaranatha Christian University WAWiku AndonotopoMaranatha Christian University

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Implication

Narrative review highlights microcirculatory dysfunction and metabolic impairment in obstetric shock, suggesting new diagnostic pathways.

Key Points

This review aims to synthesize evidence on the causes of obstetric shock beyond hemorrhage, particularly focusing on microcirculatory and metabolic dysfunctions.
Conducted literature review using PubMed/MEDLINE and PubMed Central.
Selected articles focused on obstetrics, critical care, endothelial biology, microcirculatory physiology, and mitochondrial function.
Emphasized studies with mechanistic, translational, and clinical relevance.
Identified that microcirculatory disruption, endothelial injury, and energy metabolism failure contribute to tissue hypoperfusion despite stable hemodynamics.
Described diverse clinical phenotypes associated with obstetric shock, including endothelial dysfunction-related shock and impaired oxygen utilization.
Recommended new physiological monitoring techniques for early detection of tissue hypoperfusion.

Cite This Study

Rahardjo et al. (2026) studied this question.

synapsesocial.com/papers/6a6d989ee258b358b3c6c460 https://doi.org/10.1097/fm9.0000000000000373

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Obstetric Shock Beyond Hemorrhage: Microcirculatory Shunting, Endothelial Glycocalyx Injury, and Mitochondrial Failure in Pregnancy—A Narrative Review

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Key Points

Cite This Study

Obstetric Shock Beyond Hemorrhage: Microcirculatory Shunting, Endothelial Glycocalyx Injury, and Mitochondrial Failure in Pregnancy—A Narrative Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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