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This research investigates the limitations and specific constraints of AAV vectors in regenerative medicine and cellular reprogramming.

August 1, 2026International Journal of Molecular SciencesOpen Access

AAV Vectors in Regenerative Medicine and Cellular Reprogramming: Potential, Pitfalls, and Specificity Constraints

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Authors

MAMariam abdelnabyMoscow Institute of Physics and Technology AGAdelya A. GaliakberovaPeoples' Friendship University of Russia ЭДЭ. Б. ДашинимаевPeoples' Friendship University of Russia

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Implication

This analysis reveals potential drawbacks of AAV vectors in gene therapy and cellular reprogramming, emphasizing critical limitations in iPSC engineering.

Key Points

This research investigates the limitations and specific constraints of AAV vectors in regenerative medicine and cellular reprogramming.
Assessment of barriers to efficient iPSC transduction.
Evaluation of receptor-dependent entry deficits and p53-dependent DNA damage responses.
Synthesis of evidence regarding promoter fidelity in relation to neurogenic transgene payloads.
Identification of integration events in rapidly proliferating and actively reprogramming cells despite AAV being termed non-integrating.
Demonstration that cell-type-specific promoters exhibit decreased fidelity when combined with neurogenic transgenes.
Highlighting that promoter leakage may significantly affect previously reported in vivo reprogramming efficiencies.

Cite This Study

abdelnaby et al. (2026) studied this question.

synapsesocial.com/papers/6a6d98b4e258b358b3c6c684 https://doi.org/10.3390/ijms27156846

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Implication

This analysis reveals potential drawbacks of AAV vectors in gene therapy and cellular reprogramming, emphasizing critical limitations in iPSC engineering.

AAV Vectors in Regenerative Medicine and Cellular Reprogramming: Potential, Pitfalls, and Specificity Constraints

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Implication

Key Points

Cite This Study

AAV Vectors in Regenerative Medicine and Cellular Reprogramming: Potential, Pitfalls, and Specificity Constraints

Discussion

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Implication

Key Points

Cite This Study

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