What question did this study set out to answer?

The study aims to investigate the transcriptional dynamics of Lactobacillus crispatus during different menstrual cycle phases.

August 1, 2026PLoS ONEOpen Access

Longitudinal omics study of transcriptional dynamics in Lactobacillus crispatus

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Longitudinal trial reveals phase-specific transcriptional changes in Lactobacillus crispatus, indicating its importance in vaginal health.

The study aims to investigate the transcriptional dynamics of Lactobacillus crispatus during different menstrual cycle phases.
Enrolled a healthy woman with a stable CST-I vaginal microbiome.
Collected vaginal secretion samples at six non-menstrual time points.
Applied 16S rRNA gene sequencing and metatranscriptomic sequencing for analysis.
Lactobacillus crispatus remained dominant across all sampling time points with stable community composition.
Phase-specific transcriptional reprogramming revealed upregulation of pathways for DNA replication and metabolism during the pre-ovulatory phase.
Different pathways showed significant upregulation or downregulation throughout the menstrual cycle, indicating adaptive responses.

Ren et al. (2026) studied this question.

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Longitudinal trial reveals phase-specific transcriptional changes in Lactobacillus crispatus, indicating its importance in vaginal health.