Key result
Administration of ibutilide during non-isthmus-dependent atrial flutter resulted in 2:1 left-to-right interatrial block and prolonged flutter cycle length before terminating the flutter.
Case Report (n=1)
This case report demonstrates that ibutilide can induce 2:1 left-to-right interatrial conduction block during non-isthmus-dependent atrial flutter.
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May alert to ibutilide-induced interatrial block in NIDAFL; hypothesis-generating case report requiring validation.
The effects of ibutilide on non-isthmus-dependent atrial flutter (NIDAFL) and the left atrium are not completely known. We describe a case report of 2:1 left to right interatrial block as a result of ibutilide during NIDAFL. This is a 68-year-old man with history of right atrial flutter ablation who presented with recurrence of atrial flutter and underwent a diagnostic electrophysiology study. A 20-pole catheter with 2-10-mm spacing was used spanning the cavotricuspid isthmus to the midcoronary sinus. Morphology of the flutter waves and atrial activation sequence was recorded. Ibutilide was given to terminate the atrial flutter. During administration, 2:1 left-to-right interatrial block was seen. In addition, the cycle length of the flutter prolonged, yet the activation sequence did not change. Ibutilide terminated the flutter. During sinus rhythm, interatrial block was not seen. This case report illustrates an example of 2:1 left to right interatrial conduction block because of ibutilide during a non-isthmus-dependent atrial flutter.
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ZAMBITO et al. (2009) conducted a case report in Non-isthmus-dependent atrial flutter (n=1). Ibutilide was evaluated on Termination of atrial flutter and observation of interatrial block. Administration of ibutilide during non-isthmus-dependent atrial flutter resulted in 2:1 left-to-right interatrial block and prolonged flutter cycle length before terminating the flutter.
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